Computer simulation of pharmaceutical tablet disintegration

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F17%3A43914034" target="_blank" >RIV/60461373:22340/17:43914034 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Computer simulation of pharmaceutical tablet disintegration
Original language description
The medicament can be administered to a patient in different forms, for example, as liquid syrup, semisolid ointment or solid capsules or tablets which are the most common form. Tablet usually contains a drug substance (API) and a variety of excipients (inactive ingredients) with different purpose, for example, to improve tablet stability, to modify its flavor or color, or to act as binders holding tablet together or fillers forming the necessary tablet volume. Disintegrants are excipients essential for tablet usability because they cause the rupture of the tablet and therefore promote API dissolution and its release from the tablet. The objective of this work is to create a mathematical model of the tablet composed from two constituents: excipient (disintegrant) and API. The purpose of this model is to simulate tablet disintegration and dissolution and to investigate the influence of the tablet microstructure (distribution of API and excipient within the tablet, amount of API in the tablet, size of API clusters and API/excipient dissolution rate ratio) on tablet disintegration considering percolation theory thresholds.
Czech name
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Czech description
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Project
<a href="/en/project/GA15-05534S" target="_blank" >GA15-05534S: Structure-property relationships and breakage dynamics of complex granular material</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
PROCEEDINGS 44th International Conference of the Slovak Society of Chemical Engineering
ISBN
978-80-89597-58-1
ISSN
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e-ISSN
neuvedeno
Number of pages
10
Pages from-to
867-876
Publisher name
Slovak Society of Chemical Engineering
Place of publication
Bratislava
Event location
Demänovská dolina
Event date
May 22, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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