Magnetically Controlled Liposome Aggregates for On-Demand Release of Reactive Payloads

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43916257" target="_blank" >RIV/60461373:22340/18:43916257 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.8b03891" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.8b03891</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.8b03891" target="_blank" >10.1021/acsami.8b03891</a>

Result language
angličtina
Original language name
Magnetically Controlled Liposome Aggregates for On-Demand Release of Reactive Payloads
Original language description
A colloidal system able to act as a miniature reactor for on-demand release of reactive payloads has been demonstrated. The system is based on submicrometer aggregates consisting of anionic liposomes that act as storage reservoirs for the reactants, superparamagnetic iron oxide nanoparticles (SPIONs) that enable magnetic positioning in space and controlled release of reactants from the liposomes by radiofrequency stimulation, and an oppositely charged polyelectrolyte (poly-L-lysine) that keeps the constituent elements within the aggregates at a defined ratio. The kinetics of liposome-PLL-SPION heteroaggregation was systematically mapped and a suitable composition of the liposome bilayer was found such that the system exhibits stability at ambient conditions and radiofrequency triggered release at physiological temperature. The functionality of the system was demonstrated using a reaction between resazurin and ascorbic acid. The ability to release the reactants on-demand at defined time points was demonstrated. The system opens up opportunities for the controlled local delivery of unstable of highly bioactive molecules produced in situ and on demand from stable precursors.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)

Project
<a href="/en/project/NV16-34342A" target="_blank" >NV16-34342A: Multifunctional Nano-Clusters as a Drug Delivery System</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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