Experimental analysis of inter- and intra-batch variation of granule porosity, stiffness and dissolution rate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43916259" target="_blank" >RIV/60461373:22340/18:43916259 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0263876218300790?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0263876218300790?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cherd.2018.02.014" target="_blank" >10.1016/j.cherd.2018.02.014</a>

Result language

angličtina

Original language name

Experimental analysis of inter- and intra-batch variation of granule porosity, stiffness and dissolution rate

Original language description

Using a pharmaceutical formulation, granule batches were produced at a range of granulator volumes from 0.5 L to 400 L and process conditions, characterised by the Froude number in the range from Fr = 0.26 to Fr = 1.63. The mean values and the standard deviations of granule porosity, granule stiffness and granule dissolution rate evaluated from each batch using the 400–1000 μm sieve fraction were compared in order to establish structure–property correlations. Both granule stiffness and granule dissolution rate were found linearly correlated with the Froude number. A significant intra-batch variability of all investigated granule properties was observed. The relative standard deviation of granule stiffness also increased linearly with the Froude number. Coupled experiments relating the microstructure of granules with their individual compression and dissolution curves were carried out for the first time. A surprising diversity of intra-batch granule structures and their associated dissolution rates was found in batches produced at both low and high Froude numbers, highlighting the importance of avoiding granule segregation in downstream unit operations in order to maintain consistent drug release profiles from the investigated formulation. © 2018 Institution of Chemical Engineers

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20402 - Chemical process engineering

Project

<a href="/en/project/GA15-05534S" target="_blank" >GA15-05534S: Structure-property relationships and breakage dynamics of complex granular material</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical Engineering Research and Design

ISSN

0263-8762

e-ISSN

—

Volume of the periodical

132

Issue of the periodical within the volume

Neuveden

Country of publishing house

SG - SINGAPORE

Number of pages

12

Pages from-to

1131-1142

UT code for WoS article

000430522300096

EID of the result in the Scopus database

2-s2.0-85042636273