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3D printing of tablets and films

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F18%3A43917227" target="_blank" >RIV/60461373:22340/18:43917227 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    3D printing of tablets and films

  • Original language description

    Using previously developed filaments containing two different drugs and employing a dual printerhead, multi-material tablets were successfully printed and analyzed. It was demonstrated that the release rate of both drugs can be controlled by the spatial distribution of the two materials in the tablet and predicted through mathematical modeling. However, the overall dissolution rate was lower than required, therefore, optimization of excipient composition followed. A grant proposal (TAČR Zeta) was submitted to support further experimentation in this field and optimization of the model apparatus and its conversion into commercially available software. Simultaneously, formulation for 3D printing of a prostate cancer-treating drug was prepared, employing acidoresistant excipients, which also proved to inhibit precipitation of the drug during its dissolution. In cases where excipients based on hydroxypropylmethylcellulose were used, the precipitation was successfully mitigated and the drug was converted into amorphous form. As documented previously, the a vasodilator drug was successfully printed in the form of orodispersible films (after optimization of excipient composition). Most of the necessary requirements for this formulation were met – drug purity, homogeneity and the films being detachable while staying flexible. However, the overall dissolution kinetics was too low, therefore a new parametric study of excipient composition was conducted. While the previous composition of filaments (mostly based on mixtures of cellulose- and methacrylate- based polymers) proved to be quite universal, producing printable filaments for each tested API with only minor alterations of excipient ratios, several cases of faster dissolving 3D printed tablets were reported in literature since the end of 2017. Based on the reported compositions and on literature research of hot-melt extruded fast dissolving dosage forms, new excipients were tested.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    20401 - Chemical engineering (plants, products)

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů