Multi-scale analysis of amorphous solid dispersions prepared by freeze drying of ibuprofen loaded acrylic polymer nanoparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43918064" target="_blank" >RIV/60461373:22340/19:43918064 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.jddst.2019.101182" target="_blank" >https://doi.org/10.1016/j.jddst.2019.101182</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2019.101182" target="_blank" >10.1016/j.jddst.2019.101182</a>

Result language

angličtina

Original language name

Multi-scale analysis of amorphous solid dispersions prepared by freeze drying of ibuprofen loaded acrylic polymer nanoparticles

Original language description

Amorphous solid dispersions (ASDs) consisting of ibuprofen as a model drug, and Eudragit L100-55 as methacrylate copolymer carrier, were prepared by emulsification-diffusion method followed by freeze drying of nanoparticle suspensions. Subsequently, ibuprofen-loaded Eudragit L100-55 nanoparticles with different drug loadings were prepared. To understand the processing-structure-properties relationships, multi-scale analysis was performed. Average diameter of nanoparticles in all formulations was 234 ± 30 nm. Differential scanning calorimetry, X-ray diffraction and infrared spectroscopy showed that the formulations prepared from 9 to 16% of ibuprofen were fully amorphous while nano-crystalline domains localized inside the polymeric nanoparticles thanks to the atomic force microscopy analysis were detected in formulations prepared from higher content of ibuprofen (≥20%). Unexpected increase of the entrapment efficiency with the increase of ibuprofen loading was correlated with the increase of the viscosity of the organic phase. ASDs exhibited good dissolution profiles, characterized by sustained ibuprofen release, followed by supersaturation build-up. Physical stability tests performed on the ASDs showed that ibuprofen remained amorphous after 12 months of storage period. Therefore, Eudragit L100-55 plays a dual role in the ASDs, i.e. kinetic stabilization of ibuprofen in amorphous state during the storage period, and control of the drug release, and subsequent stabilization of the supersaturated state. © 2019 Elsevier B.V.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10403 - Physical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

Říjen

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000487963600058

EID of the result in the Scopus database

2-s2.0-85069936230