Liquid Oil Marbles: Increasing the Bioavailability of Poorly Water-Soluble Drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43918619" target="_blank" >RIV/60461373:22340/19:43918619 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0022354919300760?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0022354919300760?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.xphs.2019.01.026" target="_blank" >10.1016/j.xphs.2019.01.026</a>
Alternative languages
Result language
angličtina
Original language name
Liquid Oil Marbles: Increasing the Bioavailability of Poorly Water-Soluble Drugs
Original language description
Many new therapeutic candidates and active pharmaceutical ingredients (APIs) are poorly soluble in an aqueous environment, resulting in their reduced bioavailability. A promising way of enhancing the release of an API and, thus, its bioavailability seems to be the use of liquid oil marbles (LOMs). An LOM system behaves as a solid form but consists of an oil droplet in which an already dissolved API is encapsulated by a powder. This study aims to optimize the oil/powder combination for the development of such systems. LOMs were successfully prepared for 15 oil/powder combinations, and the following properties were investigated: particle mass fraction, dissolution time, and mechanical stability. Furthermore, the release of API from both LOMs and LOMs encapsulated into gelatine capsules was studied. © 2019 American Pharmacists Association®
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20402 - Chemical process engineering
Result continuities
Project
<a href="/en/project/GJ17-21696Y" target="_blank" >GJ17-21696Y: Towards the understanding of evaporation induced pattern formation of decanol droplets</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical Sciences
ISSN
0022-3549
e-ISSN
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Volume of the periodical
108
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
2136-2142
UT code for WoS article
000477752600023
EID of the result in the Scopus database
2-s2.0-85062458524