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Liquid Oil Marbles: Increasing the Bioavailability of Poorly Water-Soluble Drugs

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43918619" target="_blank" >RIV/60461373:22340/19:43918619 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/abs/pii/S0022354919300760?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0022354919300760?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.xphs.2019.01.026" target="_blank" >10.1016/j.xphs.2019.01.026</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Liquid Oil Marbles: Increasing the Bioavailability of Poorly Water-Soluble Drugs

  • Original language description

    Many new therapeutic candidates and active pharmaceutical ingredients (APIs) are poorly soluble in an aqueous environment, resulting in their reduced bioavailability. A promising way of enhancing the release of an API and, thus, its bioavailability seems to be the use of liquid oil marbles (LOMs). An LOM system behaves as a solid form but consists of an oil droplet in which an already dissolved API is encapsulated by a powder. This study aims to optimize the oil/powder combination for the development of such systems. LOMs were successfully prepared for 15 oil/powder combinations, and the following properties were investigated: particle mass fraction, dissolution time, and mechanical stability. Furthermore, the release of API from both LOMs and LOMs encapsulated into gelatine capsules was studied. © 2019 American Pharmacists Association®

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20402 - Chemical process engineering

Result continuities

  • Project

    <a href="/en/project/GJ17-21696Y" target="_blank" >GJ17-21696Y: Towards the understanding of evaporation induced pattern formation of decanol droplets</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Pharmaceutical Sciences

  • ISSN

    0022-3549

  • e-ISSN

  • Volume of the periodical

    108

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    2136-2142

  • UT code for WoS article

    000477752600023

  • EID of the result in the Scopus database

    2-s2.0-85062458524