Population balance modelling and experimental investigation of reactive dissolution of microparticles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919307" target="_blank" >RIV/60461373:22340/19:43919307 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Population balance modelling and experimental investigation of reactive dissolution of microparticles

Original language description

Dissolution testing is widely used to predict the in-vitro performance of crystalline drugs, during the drug formulation process. However, to achieve a desired dissolution rate, many time-consuming experiments need to be conducted, because dissolution strongly depends on particle size. To eliminate the need of such experiments, we suggest a discretized population balance model, which predicts the evolution of particle size distribution and reactive dissolution over time. The model is based on a growth rate expression, derived from Noyes-Whitney equation, setting the relationship between the particle size and solubility. This expression was incorporated in a for-loop system, required to simulate the behavior of PSD and dissolution rate over time. The model evaluated two different cases: monomodal and bimodal distribution. In parallel to the model, in vitro experiments were carried out. Crystalline KCl was used as a reference compound, because KCl experiments are less time consuming. Nevertheless, its dissolution mechanism is similar to a crystalline drug. Real time changes of PSD and dissolution rate of KCl were measured in a stirred flow cell of LDA. Simulation results were compared to experimental ones for validation, by fitting two unknown parameters (diffusion coefficient and particle velocity). Our results indicate that the model is able to predict reactive dissolution and simulate similar evolution of PSD over time, in agreement with the experimental data measured.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

<a href="/en/project/GX19-26127X" target="_blank" >GX19-26127X: The robotic nano-pharmacist: Next-generation manufacturing processes for personalised therapeutic agents</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings 46th International Conference of the Slovak Society of Chemical Engineering

ISBN

978-80-8208-011-0

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

32

Publisher name

Slovak Society of Chemical Engineering

Place of publication

Bratislava

Event location

Tatranské Matliare

Event date

May 20, 2019

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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