New multimodal stationary phases prepared by Ugi multicomponent approach
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F20%3A43920604" target="_blank" >RIV/60461373:22340/20:43920604 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/20:00534797
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202000587" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/jssc.202000587</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.202000587" target="_blank" >10.1002/jssc.202000587</a>
Alternative languages
Result language
angličtina
Original language name
New multimodal stationary phases prepared by Ugi multicomponent approach
Original language description
Eight different stationary phases based on two aminopropyl silicas of different brands suitable for multimodal chromatography applications have been prepared by a four-component Ugi reaction. The intention was to synthesize stationary phases significantly differing in their properties hereby demonstrating flexibility of the Ugi synthetic protocol. Diverse functional groups including a nonpolar long aliphatic chain, phenyl moiety, cholic acid scaffold, phenylboronic and monosaccharide units, charged betaine, and arginine moieties were immobilized on a silica surface. The novel sorbents were extensively characterized by elemental analysis, Raman spectroscopy, and chromatography. Considering the anchored chemical structures covalently bonded to the silica surface, reversed-phase, hydrophilic, and ion-exchange separation modes were expected. The chromatographic evaluation was performed directed to map the potential of the individual columns specifically in the mentioned chromatographic modes. The Ugi synthetic protocol has proven to be a simple, feasible, and versatile tool for the synthesis of sorbents of variable properties. The newly prepared stationary phases differed considerably in hydrophobicity and ion-exchange ability. A significant influence of the supporting aminopropyl silica on the final chromatographic behavior was observed. Finally, one practical example confirming applicability of the newly prepared sorbents was demonstrated in separation of cytarabine.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/GA18-02597S" target="_blank" >GA18-02597S: New multibinding (pseudo)stationary phases for chromatographic and electromigration separations of (bio)molecules.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Separation Science
ISSN
1615-9306
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
22
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
4178-4190
UT code for WoS article
000575807100001
EID of the result in the Scopus database
2-s2.0-85092157397