Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922196" target="_blank" >RIV/60461373:22340/21:43922196 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/21:10435401 RIV/00064165:_____/21:10435401 RIV/68378050:_____/21:00554911 RIV/00064190:_____/21:N0000013

Result on the web

<a href="https://www.mdpi.com/1999-4923/13/11/1879/htm" target="_blank" >https://www.mdpi.com/1999-4923/13/11/1879/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pharmaceutics13111879" target="_blank" >10.3390/pharmaceutics13111879</a>

Result language

angličtina

Original language name

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design

Original language description

Designing optimal (neo)adjuvant therapy is a crucial aspect of the treatment of non-small-cell lung carcinoma (NSCLC). Standard methods of chemotherapy, radiotherapy, and immunotherapy represent effective strategies for treatment. However, in some cases with high metastatic activity and high levels of circulating tumour cells (CTCs), the efficacy of standard treatment methods is insufficient and results in treatment failure and reduced patient survival. CTCs are seen not only as an isolated phenomenon but also a key inherent part of the formation of metastasis and a key factor in cancer death. This review discusses the impact of NSCLC therapy strategies based on a meta-analysis of clinical studies. In addition, possible therapeutic strategies for repression when standard methods fail, such as the administration of low-toxicity natural anticancer agents targeting these phenomena (curcumin and flavonoids), are also discussed. These strategies are presented in the context of key mechanisms of tumour biology with a strong influence on CTC spread and metastasis (mechanisms related to tumour-associated and -infiltrating cells, epithelial-mesenchymal transition, and migration of cancer cells).

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PHARMACEUTICS

ISSN

1999-4923

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

51

Pages from-to

1879

UT code for WoS article

000728223100001

EID of the result in the Scopus database

2-s2.0-85118703352