Circulating tumor cell-derived preclinical models: current status and future perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F23%3A00574949" target="_blank" >RIV/68081707:_____/23:00574949 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/23:00132481 RIV/61989592:15110/23:73623474 RIV/00098892:_____/23:10157953 RIV/00159816:_____/23:00079743 RIV/00209805:_____/23:00079360
Result on the web
<a href="https://www.nature.com/articles/s41419-023-06059-6" target="_blank" >https://www.nature.com/articles/s41419-023-06059-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41419-023-06059-6" target="_blank" >10.1038/s41419-023-06059-6</a>
Alternative languages
Result language
angličtina
Original language name
Circulating tumor cell-derived preclinical models: current status and future perspectives
Original language description
Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by circulating tumor cells (CTCs), which originate from the primary tumor or metastatic sites and enter the bloodstream, subsequently spreading to distant parts of the body. CTCs have garnered significant attention in research due to their accessibility in peripheral blood, despite their low abundance. They are being extensively studied to gain a deeper understanding of the mechanisms underlying cancer dissemination and to identify effective therapeutic strategies for advanced stages of the disease. Therefore, substantial efforts have been directed towards establishing and characterizing relevant experimental models derived from CTCs, aiming to provide relevant tools for research. In this review, we provide an overview of recent progress in the establishment of preclinical CTC-derived models, such as CTC-derived xenografts (CDX) and cell cultures, which show promise for the study of CTCs. We discuss the advantages and limitations of these models and conclude by summarizing the potential future use of CTCs and CTC-derived models in cancer treatment decisions and their utility as precision medicine tools.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Death & Disease
ISSN
2041-4889
e-ISSN
2041-4889
Volume of the periodical
14
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
530
UT code for WoS article
001050089600001
EID of the result in the Scopus database
2-s2.0-85168257527