Comparison between two multicomponent drug delivery systems based on PEGylated-poly (L-lactide-co-glycolide) and superparamagnetic nanoparticles: Nanoparticulate versus nanocluster systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922855" target="_blank" >RIV/60461373:22340/21:43922855 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/21:43922855 RIV/70883521:28610/21:63543238
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1773224721003233?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224721003233?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jddst.2021.102643" target="_blank" >10.1016/j.jddst.2021.102643</a>
Alternative languages
Result language
angličtina
Original language name
Comparison between two multicomponent drug delivery systems based on PEGylated-poly (L-lactide-co-glycolide) and superparamagnetic nanoparticles: Nanoparticulate versus nanocluster systems
Original language description
Development of versatile and efficient multicomponent drug delivery nanocarriers in the range of hundreds of nanometers in size with tunable surface properties presents an interesting platform for biomedical applications. In this study, two approaches were evaluated for preparation of multi-component drug delivery nanocarriers based on the assembly of drug loaded PEGylated poly(L-lactide-co-glycolide) nanoparticles (PEGylated PLGA NPs) and superparamagnetic iron oxide nanoparticles (IO NPs). In the first approach, preparation of nanoclusters was performed by self-assembly of oppositely charged ibuprofen loaded PEGylated-PLGA and IO NPs, while in the second one IO NPs and a model drug (ibuprofen) were incorporated inside PEGylated PLGA NPs by single emulsion method. Nanoclusters as well as multi-component loaded PEGylated PLGA NPs with a size of 350 ± 71 nm and 238 ± 88 nm, respectively, were produced. Interestingly, both delivery systems demonstrated comparable drug release behavior after 120 h. They exhibited also comparable magnetic properties before and after dissolution tests. Mechanistic insights into the effect of the morphology and chemical composition of the multi-component delivery systems on the drug release mechanisms are proposed. © 2021 Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Drug Delivery Science and Technology
ISSN
1773-2247
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
AUG 2021
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
102643
UT code for WoS article
000674469000008
EID of the result in the Scopus database
2-s2.0-85107661356