Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F20%3A63526489" target="_blank" >RIV/70883521:28610/20:63526489 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22310/20:43921236 RIV/60461373:22340/20:43921236
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0014305720304523" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305720304523</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.eurpolymj.2020.109795" target="_blank" >10.1016/j.eurpolymj.2020.109795</a>

Result language
angličtina
Original language name
Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery
Original language description
The possibility to combine nanoparticles (NPs) with different functionalities into nanoclusters of controlled size and kinetic profile of drug release presents a promising route for the preparation of a multifunctional drug delivery system. In this study, to construct controlled drug delivery (nano)clusters, a simple and versatile method based on self-assembly via electrostatic interactions of oppositely charged poly(lactide-co-glycolide) (PLGA) and superparamagnetic iron oxide (IO) NPs was developed. Drug loaded heteroclusters with controlled size of 224 ± 52 nm and Zeta potential of −51 ± 6 mV were produced. Dissolution tests demonstrated an accelerated drug release in the heteroclusters compared to neat PLGA NPs after 24 h. This was correlated with the catalytic effect of IO NPs on the degradation of PLGA matrix. Moreover, the magnetic properties of the heteroclusters were maintained after the dissolution tests. Hence, even after drug release, the heteroclusters can be used for treatment with magnetically mediated hyperthermia.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10404 - Polymer science

Project
<a href="/en/project/NV16-34342A" target="_blank" >NV16-34342A: Multifunctional Nano-Clusters as a Drug Delivery System</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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