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Rifampicin-loaded PLGA nanoparticles for local treatment of musculoskeletal infections: Formulation and characterization

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019216" target="_blank" >RIV/62690094:18470/22:50019216 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/22:10444240 RIV/00216208:11160/22:10444240 RIV/00179906:_____/22:10444240

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1773224722003458" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224722003458</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jddst.2022.103435" target="_blank" >10.1016/j.jddst.2022.103435</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Rifampicin-loaded PLGA nanoparticles for local treatment of musculoskeletal infections: Formulation and characterization

  • Original language description

    Systemic treatment of orthopedic device-related infections requires potentially toxic doses to reach local therapeutic levels. A locally applied nanosized drug delivery system can provide a high drug dose at the target site. Branched PLGA of lower molar mass was used for rifampicin-loaded nanoparticles (RIF-NPs) formulation by the nanoprecipitation method. The formulation variables influenced the NPs size ranging from 200 to 380 nm. The missing peak of crystalline rifampicin on the DSC scan of the NPs indicates that the drug was molecularly dispersed. The negative charge of the NPs in the physiological buffer was masked by a nonionic surfactant or converted to a positive one by a cationic surfactant, which promotes bioadhesion, penetration, and antimicrobial effect of locally applied RIF-NPs without being toxic to proliferation. Low values of loading capacity showed that PLGA predominates in the NPs, which, however, perform their function as a drug carrier ensuring sustained RIF release. The ex vivo dissolution study of RIF-NPs impregnated into the cancellous allogeneic bone grafts showed a low initial burst followed by sustained release of RIF for 7 days. Rifampicin-loaded PLGA nanoparticles may contribute to the prevention of resistant biofilm formation in patients with implanted devices and the local treatment of infections in open musculoskeletal injuries.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

  • ISSN

    1773-2247

  • e-ISSN

    2588-8943

  • Volume of the periodical

    73

  • Issue of the periodical within the volume

    JUL 2022

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    8

  • Pages from-to

    "Article Number: 103435"

  • UT code for WoS article

    000806232000005

  • EID of the result in the Scopus database

    2-s2.0-85130230828