Rifampicin-loaded PLGA nanoparticles for local treatment of musculoskeletal infections: Formulation and characterization
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50019216" target="_blank" >RIV/62690094:18470/22:50019216 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/22:10444240 RIV/00216208:11160/22:10444240 RIV/00179906:_____/22:10444240
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1773224722003458" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224722003458</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jddst.2022.103435" target="_blank" >10.1016/j.jddst.2022.103435</a>
Alternative languages
Result language
angličtina
Original language name
Rifampicin-loaded PLGA nanoparticles for local treatment of musculoskeletal infections: Formulation and characterization
Original language description
Systemic treatment of orthopedic device-related infections requires potentially toxic doses to reach local therapeutic levels. A locally applied nanosized drug delivery system can provide a high drug dose at the target site. Branched PLGA of lower molar mass was used for rifampicin-loaded nanoparticles (RIF-NPs) formulation by the nanoprecipitation method. The formulation variables influenced the NPs size ranging from 200 to 380 nm. The missing peak of crystalline rifampicin on the DSC scan of the NPs indicates that the drug was molecularly dispersed. The negative charge of the NPs in the physiological buffer was masked by a nonionic surfactant or converted to a positive one by a cationic surfactant, which promotes bioadhesion, penetration, and antimicrobial effect of locally applied RIF-NPs without being toxic to proliferation. Low values of loading capacity showed that PLGA predominates in the NPs, which, however, perform their function as a drug carrier ensuring sustained RIF release. The ex vivo dissolution study of RIF-NPs impregnated into the cancellous allogeneic bone grafts showed a low initial burst followed by sustained release of RIF for 7 days. Rifampicin-loaded PLGA nanoparticles may contribute to the prevention of resistant biofilm formation in patients with implanted devices and the local treatment of infections in open musculoskeletal injuries.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
ISSN
1773-2247
e-ISSN
2588-8943
Volume of the periodical
73
Issue of the periodical within the volume
JUL 2022
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
"Article Number: 103435"
UT code for WoS article
000806232000005
EID of the result in the Scopus database
2-s2.0-85130230828