Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922864" target="_blank" >RIV/60461373:22340/21:43922864 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.powtec.2020.10.081" target="_blank" >https://doi.org/10.1016/j.powtec.2020.10.081</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2020.10.081" target="_blank" >10.1016/j.powtec.2020.10.081</a>
Alternative languages
Result language
angličtina
Original language name
Frequency analysis of stress relaxation patterns reveals the effect of formulation and process history on tablet disintegration
Original language description
Tablets are the most common pharmaceutical dosage form. Being compressed from smaller particles or granules, the disintegration rate of tablets in the gastro-intestinal tract is a key property that strongly influences the rate of drug release. While established methods for in vitro tablet disintegration measurement provide information about the final disintegration time, a more detailed analysis of the disintegration process can be a rich source of additional information. In this work, a new method of tablet disintegration monitoring based on real-time recording of stress relaxation curves in tablets after immersion in the dissolution medium is presented. The signal is recorded using a texture analyzer with a needle probe, and then processed to reveal structural changes in the disintegrating tablet. It is shown that the frequency and amplitude of fluctuations on the stress relaxation curve are uniquely able to capture parameters such as the disintegrant content and the particle size of the drug and excipients from which the tablet was made. Moreover, the method is highly sensitive to variations in the composition of dissolution media; it can therefore be used during formulation development, biopharmaceutical analysis and for the general understanding of process-property relationships of compacted granular materials. © 2020
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
<a href="/en/project/GX19-26127X" target="_blank" >GX19-26127X: The robotic nano-pharmacist: Next-generation manufacturing processes for personalised therapeutic agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Powder Technology
ISSN
0032-5910
e-ISSN
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Volume of the periodical
379
Issue of the periodical within the volume
February 2021
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
438-446
UT code for WoS article
000608255900011
EID of the result in the Scopus database
2-s2.0-85097896594