The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875627" target="_blank" >RIV/62157124:16370/17:43875627 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2015.1089900" target="_blank" >http://dx.doi.org/10.3109/10837450.2015.1089900</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2015.1089900" target="_blank" >10.3109/10837450.2015.1089900</a>
Alternative languages
Result language
angličtina
Original language name
The effect of superdisintegrants on the properties and dissolution profiles of liquisolid tablets containing rosuvastatin
Original language description
Context: The preparation of liquisolid systems (LSS) represents a promising method for enhancing a dissolution rate and bioavailability of poorly soluble drugs. The release of the drug from LSS tablets is affected by many factors, including the disintegration time. Objective: The evaluation of differences among LSS containing varying amounts and types of commercially used superdisintegrants (Kollidon (R) CL-F, Vivasol (R) and Explotab (R)). Materials and methods: LSS were prepared by spraying rosuvastatin solution onto Neusilin (R) US2 and further processing into tablets. Varying amounts of superdisintegrants were used and the differences among LSS were evaluated. The multiple scatter plot method was used to visualize the relationships within the obtained data. Results and discussion: All disintegrants do not showed negative effect on the flow properties of powder blends. The type and concentration of superdisintegrant had an impact on the disintegration time and dissolution profiles of tablets. Tablets with Explotab (R) showed the longest disintegration time and the smallest amount of released drug. Fastest disintegration and dissolution rate were observed in tablets containing Kollidon (R) CL-F (>= 2.5% w/w). Also tablets with Vivasol (R) (2.5-4.0% w/w) showed fast disintegration and complete drug release. Conclusion: Kollidon (R) CL-F and Vivasol (R) in concentration >= 2.5% are suitable superdisintegrants for LSS with enhanced release of drug.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical development and technology
ISSN
1083-7450
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
138-147
UT code for WoS article
000394648300003
EID of the result in the Scopus database
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