Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876652" target="_blank" >RIV/62157124:16370/18:43876652 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1208/s12249-018-1088-y" target="_blank" >http://dx.doi.org/10.1208/s12249-018-1088-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1208/s12249-018-1088-y" target="_blank" >10.1208/s12249-018-1088-y</a>
Alternative languages
Result language
angličtina
Original language name
Development of Orodispersible Films Containing Benzydamine Hydrochloride Using a Modified Solvent Casting Method
Original language description
The aim of this study was to develop benzydamine hydrochloride-loaded orodispersible films using the modification of a solvent casting method. An innovative approach was developed when the drying process of a small-scale production was used based on a heated inert base for casting the film. During this process, two types of film-forming maltodextrins for rapid drug delivery were used. They were plasticized with two different polyols (xylitol and sorbitol). Superdisintegrant KollidonA (R) CL-F was tested as an excipient that can induce faster disintegration of the prepared films. The influence of the formulation parameters (dextrose equivalent of film-forming maltodextrins, a type of plasticizer, and the presence of superdisintegrant) on the disintegration time, mechanical properties, and moisture content of films was statistically evaluated using a multivariate data analysis. Orodispersible films containing maltodextrin with lower dextrose equivalent value showed better mechanical properties (tensile strength ranged from 886.6 +/- 30.2 to 1484.2 +/- 226.9 N cm(-2)), lower moisture content (0.5 +/- 0.0 to 1.2 +/- 0.2%), and shorter disintegration time (17.6 +/- 2.9 to 27.8 +/- 2.8 s). Films plasticized with xylitol showed shorter disintegration time (17.6 +/- 2.9 to 29.2 +/- 3.8 s) than films containing sorbitol (23.8 +/- 2.9 to 31.7 +/- 3.9 s). With the addition of superdisintegrant KollidonA (R) CL-F, a significant influence on disintegration time was not observed. The modified solvent casting method shows great promise in a small-scale laboratory production of orodispersible films, e.g., in a pharmacy lab.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
AAPS PharmSciTech
ISSN
1530-9932
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2509-2518
UT code for WoS article
000440308000007
EID of the result in the Scopus database
2-s2.0-85048369928