Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid System Properties

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875603" target="_blank" >RIV/62157124:16370/17:43875603 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/17:10364244

Result on the web

<a href="http://dx.doi.org/10.1016/j.xphs.2016.11.002" target="_blank" >http://dx.doi.org/10.1016/j.xphs.2016.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.xphs.2016.11.002" target="_blank" >10.1016/j.xphs.2016.11.002</a>

Result language

angličtina

Original language name

Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid System Properties

Original language description

The preparation of liquisolid systems presents a promising and innovative possibility for enhancing dissolution profiles and improving the bioavailability of poorly soluble drugs. This study aims to evaluate the differences in the properties of liquisolid systems containing combinations of 3 commercially used superdisintegrants (sodium starch glycolate, crospovidone, and croscarmellose sodium). Multiple regression models and contour plots were used to study how the amount and the type of superdisintegrant used affected the quality parameters of liquisolid tablets. The results revealed that an increased amount of crospovidone in the mixture improves disintegration and wetting time and enhances drug release from the prepared liquisolid tablets. Moreover, it was observed that a binary blend of crospovidone and sodium starch glycolate improved tablet disintegration. Considering the obtained results, it could be stated that crospovidone showed the best properties to be used as superdisintegrant for the preparation of liquisolid systems containing rosuvastatin.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pharmaceutical sciences

ISSN

0022-3549

e-ISSN

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Volume of the periodical

106

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

817-825

UT code for WoS article

000400398400016

EID of the result in the Scopus database

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