Modern Evaluation of Liquisolid Systems with Varying Amounts of Liquid Phase Prepared Using Two Different Methods
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873516" target="_blank" >RIV/62157124:16370/15:43873516 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2015/608435" target="_blank" >http://dx.doi.org/10.1155/2015/608435</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/608435" target="_blank" >10.1155/2015/608435</a>
Alternative languages
Result language
angličtina
Original language name
Modern Evaluation of Liquisolid Systems with Varying Amounts of Liquid Phase Prepared Using Two Different Methods
Original language description
Liquisolid systems are an innovative dosage form used for enhancing dissolution rate and improving in vivo bioavailability of poorly soluble drugs.These formulations require specific evaluation methods for their quality assurance (e.g., evaluation of angle of slide, contact angle, or water absorption ratio). The presented study is focused on the preparation, modern in vitro testing, and evaluation of differences of liquisolid systems containing varying amounts of a drug in liquid state (polyethylene glycol 400 solution of rosuvastatin) in relation to an aluminometasilicate carrier (Neusilin US2). Liquisolid powders used for the formulation of final tablets were prepared using two different methods: simple blending and spraying of drug solution onto a carrier in fluid bed equipment. The obtained results imply that the amount of liquid phase in relation to carrier material had an effect on the hardness, friability, and disintegration of tablets, as well as their height. The use of sprayi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
Neuveden
Issue of the periodical within the volume
2015
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"Nestránkováno"
UT code for WoS article
000355438700001
EID of the result in the Scopus database
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