Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873547" target="_blank" >RIV/62157124:16370/15:43873547 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2014.926921" target="_blank" >http://dx.doi.org/10.3109/10837450.2014.926921</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2014.926921" target="_blank" >10.3109/10837450.2014.926921</a>
Alternative languages
Result language
angličtina
Original language name
Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation
Original language description
Context: Liquisolid systems are modern formulations used to increase the bioavailability of poorly water-soluble drugs. Their preparation is based on the sorption of a drug in liquid state onto a carrier with a high adsorption capacity. The carrier particles are subsequently coated with material having a large surface area to form free-flowing powder. The main principle of bioavailability increasing is based on the presence of the dissolved drug, which is ready for immediate absorption in GI tract. Objective: Determination of capability of aluminometasilicate carrier Neusilin (R) US2 to adsorb different solvents. Materials and methods: The maximum amounts of polyethylene glycol 200 (PEG 200), polyethylene glycol 400 and propylene glycol (PG), which canbe sorbed by Neusilin (R) US2, while maintaining an acceptable flowability of the powder mixture, were evaluated using determination of the flowable liquid retention potential. Results and discussion: From the evaluation of liquisolid po
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
ISSN
1083-7450
e-ISSN
—
Volume of the periodical
20
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
839-844
UT code for WoS article
000361337500009
EID of the result in the Scopus database
—