Optimization of Wurster fluid bed coating: Mathematical model validated against pharmaceutical production data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922885" target="_blank" >RIV/60461373:22340/21:43922885 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.powtec.2021.03.059" target="_blank" >https://doi.org/10.1016/j.powtec.2021.03.059</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.powtec.2021.03.059" target="_blank" >10.1016/j.powtec.2021.03.059</a>

Result language
angličtina
Original language name
Optimization of Wurster fluid bed coating: Mathematical model validated against pharmaceutical production data
Original language description
Wurster fluid bed coating is an effective way of manufacturing pharmaceutical pellets requiring specific characteristics such as high drug loading or enteric protection. The optimization of coating process can be demanding because it necessitates many time-consuming experiments. To reduce the need for experiments and prevent undesired agglomeration, a multi-scale model has been developed. On the device-scale, the model predicts the temperature, moisture content, and average coating thickness. On the micro-scale, the model estimates the evaporation time of a single sessile droplet. By coupling models at both length-scales, it is possible to evaluate droplet evaporation time as a function of process parameters and use it as a tool for process transfer between different production sites and equipment. The model was validated against existing production data. The predicted outlet air temperature was in good agreement, and most importantly, the predicted values of the evaporation time separated undesired agglomeration and successful coating regime. © 2021 Elsevier B.V.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20401 - Chemical engineering (plants, products)

Project
<a href="/en/project/GX19-26127X" target="_blank" >GX19-26127X: The robotic nano-pharmacist: Next-generation manufacturing processes for personalised therapeutic agents</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)