Development of compartmentalized antibacterial systems based on encapsulated alliinase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43923373" target="_blank" >RIV/60461373:22340/21:43923373 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/21:00543641

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0921883121002806?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0921883121002806?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apt.2021.05.045" target="_blank" >10.1016/j.apt.2021.05.045</a>

Result language

angličtina

Original language name

Development of compartmentalized antibacterial systems based on encapsulated alliinase

Original language description

Allicin, an organic compound produced via the transformation of biologically inactive alliin by alliinase, an enzyme found in garlic, combines a strong antibacterial effect with suppressed development of bacterial resistance. However, because of the high reactivity and volatility, controlled in-situ production of allicin that mimics the natural synthesis is essential to achieve desired therapeutic effects. In this work, the spray-drying technique was employed for encapsulation of alliinase into polymer micro-carriers with an emphasis on the effect of process parameters, i.e., drying temperature, nozzle type, choice of the carrier materials, on the activity of encapsulated alliinase in soluble maltodextrin and swellable chitosan microparticles. The results show that maltodextrin is a suitable carrier for the effective protection of alliinase against thermal stress. On the other hand, we can control allicin production and release from chitosan carriers with immobilized alliinase by variation of the cross-linker amount. Antibacterial activity of in-situ formed allicin vapors was confirmed against Escherichia coli bacterial strain using customized sample holders preventing physical contact of powder sample with the inoculated agar plate. © 2021 The Society of Powder Technology Japan

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Advanced Powder Technology

ISSN

0921-8831

e-ISSN

—

Volume of the periodical

32

Issue of the periodical within the volume

8

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

13

Pages from-to

2720-2732

UT code for WoS article

000681313400005

EID of the result in the Scopus database

2-s2.0-85108543289