Design and evaluation of composite films for in situ synthesis and antibacterial activity of allicin vapour

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F24%3A00587985" target="_blank" >RIV/61388963:_____/24:00587985 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22330/24:43931104 RIV/60461373:22340/24:43931104

Result on the web

<a href="https://doi.org/10.1007/s10853-024-09990-x" target="_blank" >https://doi.org/10.1007/s10853-024-09990-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10853-024-09990-x" target="_blank" >10.1007/s10853-024-09990-x</a>

Result language

angličtina

Original language name

Design and evaluation of composite films for in situ synthesis and antibacterial activity of allicin vapour

Original language description

Although allicin has potent antibiotic properties, its low stability, which is responsible for its persistent biological activity, has posed a significant challenge to its practical application in modern medicine. To harness the healing benefits of this phytochemical, known by humans for thousands of years, we propose a controlled in situ synthesis of allicin vapour near the site of infection. Considering the critical need for novel approaches to prevent pandemic scenarios caused by MDR bacteria, we suggest encapsulating and physically separating allicin precursors (substrate alliin and enzyme alliinase) in alginate-based films and spray-dried chitosan microparticles. The mechanical properties of the hydrogel films of various compositions were evaluated, as well as their ability to protect the encapsulated alliinase against thermal stress and control the overall rate of allicin release upon hydration. Furthermore, the non-contact antibacterial efficacy of free alliin/alliinase reaction mixture (aqueous solution) and three compartmentalised configurations, i.e. film-solution, film-particles, and double-film, were tested against selected bacterial strains, i.e. E. coli, S. epidermidis, and S. aureus. The results indicate that the formation of allicin vapour using the proposed compartmentalised systems addresses allicin’s stability issues and provides better control over the rate of allicin production. The observed antibacterial effect was comparable with directly formed allicin using higher initial amounts of both substances, which is given by diffusion limitations associated with encapsulation. These findings illustrate the potential of compartmentalised systems in developing nature-based wound dressings for infection prevention and promoting healing.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA23-07356S" target="_blank" >GA23-07356S: Development of inhalable carriers for in-situ production of natural antibiotics</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Materials Science

ISSN

0022-2461

e-ISSN

1573-4803

Volume of the periodical

59

Issue of the periodical within the volume

29

Country of publishing house

DE - GERMANY

Number of pages

18

Pages from-to

13614-13631

UT code for WoS article

001269477000004

EID of the result in the Scopus database

2-s2.0-85198756597