The impact of the lamination pressure on the properties of electrospinned nanofibrous films
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43925019" target="_blank" >RIV/60461373:22340/22:43925019 - isvavai.cz</a>
Alternative codes found
RIV/46747885:24510/22:00010436
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0928098722000550?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928098722000550?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejps.2022.106170" target="_blank" >10.1016/j.ejps.2022.106170</a>
Alternative languages
Result language
angličtina
Original language name
The impact of the lamination pressure on the properties of electrospinned nanofibrous films
Original language description
The purpose of this work is to explore the preparation of nanofibrous orally dispersible films (ODFs) by needleless electrospinning from the active pharmaceutical ingredient (API) Tadalafil using particles suspended in a solution of polymers and other excipients. The prepared films were characterized by a combination of scanning electron microscopy, mechanical tests, measurements of the disintegration time and dissolution characteristic, X-ray diffraction, and differential scanning calorimetry. Furthermore, we investigated the impact of lamination pressures in the range of 0 to 5 bars combined with films at various relative humidity values on the mechanical properties of the ODF. An increase in lamination pressure resulted in higher Young's modulus values, with the maximum value observed for a sample laminated at a pressure of 5 bar and the maximum stress and strain of the prepared ODF at a lamination pressure of 1.2 bar. Moreover, there was a significant increase in the disintegration time with increase in lamination pressure. The disintegration time ranged from 0.35 s for non-laminated samples to 12 s for samples laminated at a pressure of 5 bar. On the contrary, the lamination pressure did not reveal to have any impact on the dissolution kinetics. These results confirmed that the lamination pressure can improve the processability of ODFs without affecting the API dissolution kinetics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20401 - Chemical engineering (plants, products)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Pharmaceutical Sciences
ISSN
0928-0987
e-ISSN
1879-0720
Volume of the periodical
173
Issue of the periodical within the volume
JUN 1 2022
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
106170
UT code for WoS article
000806400200001
EID of the result in the Scopus database
2-s2.0-85127749649