3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F23%3A43926426" target="_blank" >RIV/60461373:22340/23:43926426 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2095177923000187" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2095177923000187</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jpha.2023.02.004" target="_blank" >10.1016/j.jpha.2023.02.004</a>

Result language

angličtina

Original language name

3D Raman mapping as an analytical tool for investigating the coatings of coated drug particles

Original language description

The properties of dry-coated paracetamol particles (fast-dissolving model drug) with carnauba wax particles as the coating agent (dissolution retardant) were investigated. Raman mapping technique was used to non-destructively examine the thickness and homogeneity of coated particles. The results showed that the wax existed in two forms on the surface of the paracetamol particles, forming a porous coating layer: i) whole wax particles on the surface of paracetamol and glued together with other wax surface particles, and ii) deformed wax particles spread on the surface. Regardless of the final particle size fraction (between 100 and 800 μm), the coating thickness had high variability, with average thickness of 5.9 ± 4.2 μm. The ability of carnauba wax to decrease the dissolution rate of paracetamol was confirmed by dissolution of powder and tablet formulations. The dissolution was slower for larger coated particles. Tableting further reduced the dissolution rate, clearly indicating the impact of subsequent formulation processes on the final quality of the product. © 2023 The Author(s)

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Pharmaceutical Analysis

ISSN

2095-1779

e-ISSN

2214-0883

Volume of the periodical

13

Issue of the periodical within the volume

3

Country of publishing house

CN - CHINA

Number of pages

11

Pages from-to

276-286

UT code for WoS article

000977847600001

EID of the result in the Scopus database

2-s2.0-85149666992