Spray drying robot for high-throughput combinatorial fabrication of multicomponent solid dispersions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F23%3A43927252" target="_blank" >RIV/60461373:22340/23:43927252 - isvavai.cz</a>

Result on the web

<a href="https://www.scopus.com/record/display.uri?origin=resultslist&eid=2-s2.0-85167589686" target="_blank" >https://www.scopus.com/record/display.uri?origin=resultslist&eid=2-s2.0-85167589686</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2023.118872" target="_blank" >10.1016/j.powtec.2023.118872</a>

Result language

angličtina

Original language name

Spray drying robot for high-throughput combinatorial fabrication of multicomponent solid dispersions

Original language description

During the development of pharmaceutical spray-dried formulations, many samples must be prepared for physico-chemical characterisation and dissolution testing by systematically varying parameters such as drug loading or the grades and ratios of excipients (polymers, surfactants, etc.). When spray drying from organic solvents in a traditional laboratory set-up, the process must be stopped after producing each sample and then re-started, which makes combinatorial exploration of the formulation design space rather time-consuming. The present work reports a new approach using a device built around a commercially available laboratory spray dryer, which enables the preparation of powder samples with systematically varying composition within a single spray drying run. The device consists of three main parts whose purpose is to achieve: i) automatic combinatorial preparation of feed mixtures from up to 9 different stock solutions; ii) removal of adhered particles from the internal glass walls of the cyclone to minimise sample cross-contamination; and iii) automatic collection of individual powder samples in sealed vials without breaking the inert atmosphere. To validate the device operation and to demonstrate its ability to produce sets of powder samples in a short time, two cases studies were conducted: a model system with ternary mixtures of coloured lactose, and a pharmaceutical co-amorphous formulation with two actives and a polymeric excipient. The case studies show that an identical set of samples can be produces by up to 8× faster compared to manual screening, while keeping sample cross-contamination at around 1%. Ultimately, this can significantly increase the throughput of data collection and analysis during powder formulation studies.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

20401 - Chemical engineering (plants, products)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Powder Technology

ISSN

0032-5910

e-ISSN

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Volume of the periodical

428

Issue of the periodical within the volume

07082023

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

"Neuvedeno"

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85167589686