Simulation of Complex Biomolecular Systems: The Ribosome Challenge
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F23%3A43927813" target="_blank" >RIV/60461373:22340/23:43927813 - isvavai.cz</a>
Result on the web
<a href="https://www.annualreviews.org/doi/10.1146/annurev-biophys-111622-091147#_i24" target="_blank" >https://www.annualreviews.org/doi/10.1146/annurev-biophys-111622-091147#_i24</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1146/annurev-biophys-111622-091147" target="_blank" >10.1146/annurev-biophys-111622-091147</a>
Alternative languages
Result language
angličtina
Original language name
Simulation of Complex Biomolecular Systems: The Ribosome Challenge
Original language description
Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied by computer simulations. Pushing the limits of length- and timescales that can be accessed by current hard- and software has expanded the ability to describe biomolecules at different levels of detail. We focus in this review on the ribosome, which exemplifies the close interplay between experiment and various simulation approaches, as a particularly challenging and prototypic nanomachine that is pivotal to cellular biology due to its central role in translation. We sketch widely used simulation methods and demonstrate how the combination of simulations and experiments advances our understanding of the function of the translation apparatus based on fundamental physics. © 2023 by the author(s).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/GJ19-06479Y" target="_blank" >GJ19-06479Y: Structure and dynamics of the ribosome exit tunnel</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Annual Review of Biophysics
ISSN
1936-122X
e-ISSN
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Volume of the periodical
52
Issue of the periodical within the volume
May
Country of publishing house
US - UNITED STATES
Number of pages
30
Pages from-to
361-390
UT code for WoS article
000982017100017
EID of the result in the Scopus database
2-s2.0-85159563407