Improving QCM Biosensor Efficiency by Flow Cell Modification
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F25%3A43933489" target="_blank" >RIV/60461373:22340/25:43933489 - isvavai.cz</a>
Result on the web
<a href="http://www2.it.cas.cz/fm/im/im/proceeding/2025/21" target="_blank" >http://www2.it.cas.cz/fm/im/im/proceeding/2025/21</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14311/TPFM.2025.021" target="_blank" >10.14311/TPFM.2025.021</a>
Alternative languages
Result language
angličtina
Original language name
Improving QCM Biosensor Efficiency by Flow Cell Modification
Original language description
Biosensors based on quartz crystal microbalance (QCM) are often used for detection of biomolecules, pathogens, or viruses. The biological analyte gets captured at the QCM crystal surface, leading to a change in the crystal resonant frequency and analyte detection. However, with standard biosensor geometry, most of the analyte is captured in regions where the crystal sensitivity is limited. In this work, we investigate how changes in the biosensor geometry influence the spatial distribution of the captured analyte. Using a custom implementation of an immersed boundary method, we add obstacles on the non-detecting top wall of the biosensor flow cell, which is motivated by the possibility to 3D print this surface. Next, we simulate the biomolecules as Lagrangian particles with the Brownian motion taken into account and evaluate the probability of the analyte detection. Several different variants of obstacle shapes and layouts were tested. With the best obstacle configuration found, the amount of analyte captured in the most sensitive region of the crystal was 17% higher than in the standard configuration. The obtained results may be used (i) to generate QCM sensor geometries and validate this computational study, and (ii) as a basis for the development of less computationally demanding models usable in automatic optimization of the QCM biosensor geometry.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10102 - Applied mathematics
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Topical Problems of Fluid Mechanics 2025
ISBN
978-80-87012-05-5
ISSN
2336-5781
e-ISSN
—
Number of pages
8
Pages from-to
159-166
Publisher name
Ústav termomechaniky AV ČR, v.v.i.
Place of publication
Praha
Event location
Praha
Event date
Feb 12, 2025
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
001597458700021