Radial flow enhances QCM biosensor sensitivity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F24%3A00585171" target="_blank" >RIV/68378271:_____/24:00585171 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.snb.2023.134949" target="_blank" >https://doi.org/10.1016/j.snb.2023.134949</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2023.134949" target="_blank" >10.1016/j.snb.2023.134949</a>

Result language
angličtina
Original language name
Radial flow enhances QCM biosensor sensitivity
Original language description
QCM biosensors are widely used for the detection of a variety of pathogenic microorganisms, and there remains a need for further increases in sensitivity. The majority of QCM biosensors are operated under diffusion-limited conditions that, when used with a standard flow cell, lead to the majority of analyte being captured onto re- gions of the crystal surface that have limited to no mass sensitivity. Here we show that simple changes to a flow cell architecture (reduction of flow cell height) can provide increases in sensing signal. Furthermore, we show that the use of radial flow will lead to analyte capture directly in the sensitive region of a crystal, thus providing dramatic increases in the biosensor’s sensitivity. We examine this problem from both a theoretical and numerical perspective and present a new method by which to consider how changes to a sensing assay will affect sensor sensitivity.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10610 - Biophysics

Project
<a href="/en/project/GA22-20012S" target="_blank" >GA22-20012S: Elucidating and eliminating biosensor fouling via 3D nanostructured polymer brush microarrays</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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