Enhancement of affinity-based biosensors: effect of sensing chamber geometry on sensitivity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F13%3A00396513" target="_blank" >RIV/67985882:_____/13:00396513 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/c2lc41184a" target="_blank" >http://dx.doi.org/10.1039/c2lc41184a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c2lc41184a" target="_blank" >10.1039/c2lc41184a</a>

Result language

angličtina

Original language name

Enhancement of affinity-based biosensors: effect of sensing chamber geometry on sensitivity

Original language description

Affinity-based biosensing systems have become an important analytical tool for the detection and study of numerous biomolecules. The merging of these sensing technologies with microfluidic flow cells allows for faster detection times, increased sensitivities, and lower required sample volumes. In order to obtain a higher degree of performance from the sensor, it is important to know the effects of the flow cell geometry on the sensor sensitivity. In these sensors, the sensor sensitivity is related to the overall diffusive flux of analyte to the sensing surface; therefore increases in the analyte flux will be manifested as an increase in sensitivity, resulting in a lower limit of detection (LOD). Here we present a study pertaining to the effects of theflow cell height H on the analyte flux J, where for a common biosensor design we predict that the analyte flux will scale as J approximate to H-2/3. We verify this scaling behavior via both numerical simulations as well as an experimental

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BH - Optics, masers and lasers

OECD FORD branch

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Project

<a href="/en/project/GBP205%2F12%2FG118" target="_blank" >GBP205/12/G118: Nanobiophotonics for future health care</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Lab on a Chip

ISSN

1473-0197

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1413-1421

UT code for WoS article

000315688500025

EID of the result in the Scopus database

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