Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1? via TLR4/MyD88/TRIF/MAPK/NF-?B Signaling Pathway and an NLRP3Inflammasome Activation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F13%3A0031" target="_blank" >RIV/61383082:_____/13:0031 - isvavai.cz</a>
Result on the web
<a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062426;jsessionid=6EC66B03090BFC57475FF7544332698C" target="_blank" >http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062426;jsessionid=6EC66B03090BFC57475FF7544332698C</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0062426" target="_blank" >10.1371/journal.pone.0062426</a>

Result language
angličtina
Original language name
Pepsin Digest of Wheat Gliadin Fraction Increases Production of IL-1? via TLR4/MyD88/TRIF/MAPK/NF-?B Signaling Pathway and an NLRP3Inflammasome Activation
Original language description
Celiac disease (CD) is a gluten-responsive, chronic inflammatory enteropathy. IL-1 cytokine family members IL-1? and IL-18 have been associated with the inflammatory conditions in CD patients. However, the mechanisms of IL-1 molecule activation in CD have not yet been elucidated. We show in this study that peripheral blood mononuclear cells (PBMC) and monocytes from celiac patients responded to pepsin digest of wheat gliadin fraction (PDWGF) by a robust secretion of IL-1? and IL-1? and a slightly elevated production of IL-18.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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