Effect of antiviral treatment of chronic hepatitis C on the frequency of regulatory T cells, T-cell activation, and serum levels of TGF-beta

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F16%3A00000278" target="_blank" >RIV/61383082:_____/16:00000278 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/16:10327388 RIV/00216208:11150/16:10327388 RIV/00179906:_____/16:10327388 RIV/00064211:_____/16:N0000017
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/apm.12561/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/apm.12561/abstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/apm.12561" target="_blank" >10.1111/apm.12561</a>

Result language
angličtina
Original language name
Effect of antiviral treatment of chronic hepatitis C on the frequency of regulatory T cells, T-cell activation, and serum levels of TGF-beta
Original language description
The aim was to analyze T-regulatory cells (Tregs), activated CD8(+) T cells, and transforming growth factor-beta (TGF)- in hepatitis C patients. We enrolled 31 patients with chronic genotype 1 hepatitis C virus (HCV) infection, 30 seropositive persons with spontaneous HCV elimination, and 23 healthy volunteers. The patients were examined at the beginning of the interferon-alpha (IFN-)-based therapy (baseline) and at weeks 4 (W4) and 12 (W12) of the therapy. The percentage of Tregs and the expression of activation markers CD38 and HLA-DR on CD8(+) T cells were analyzed in the peripheral blood by flow cytometry. Serum levels of TGF- were measured in a multiplex assay using flow cytometry. The percentage of Tregs in patients was higher than in controls and seropositive persons. Similarly, the percentage of CD8(+) T cells expressing CD38 and HLA-DR was higher in patients compared with controls and seropositive persons. Chronic HCV infection is associated with elevated circulating Tregs and activated CD8(+) T cells. During IFN--based therapy these cells gradually increase, whereas TGF- serum levels decrease.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/NT14072" target="_blank" >NT14072: Predictive immunological markers in patients with hepatitis C viral infection</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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