Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F19%3A00000489" target="_blank" >RIV/61383082:_____/19:00000489 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/19:10398551 RIV/00216208:11130/19:10398551 RIV/00843989:_____/19:E0107974

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/31582902" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/31582902</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2019/6985703" target="_blank" >10.1155/2019/6985703</a>

Result language

angličtina

Original language name

Calprotectin and Calgranulin C as Biomarkers of Pancreatic Tumors: Baseline Levels and Level Changes after Surgery

Original language description

Pancreatic tumors and their surgical resection are associated with significant morbidity and mortality, and the biomarkers currently used for these conditions have limited sensitivity and specificity. Because calprotectin and calgranulin C serum levels have been demonstrated to be potential biomarkers of certain cancers and complications of major surgery, the levels of both proteins were tested in the current study in patients with benign and malignant pancreatic tumors that were surgically removed. The baseline serum levels and kinetics of calprotectin and calgranulin C during the 7-day postoperative period were evaluated with immunoassays in 98 adult patients who underwent pancreatic surgery. The baseline serum levels of calprotectin and calgranulin C in patients with malignant (n=84) and benign tumors (n=14) were significantly higher (p<0.01) when compared to those in the healthy controls (n=26). The serum levels of both proteins were also significantly (p<0.05) higher in patients with benign tumors than in those with malignant tumors. After surgery, the serum levels of calprotectin and calgranulin C were significantly (p<0.01) higher than their baseline values, and this elevation persisted throughout the seven days of the follow-up period. Interestingly, starting on day 1 of the postoperative period, the serum levels of both proteins were significantly (p<0.05) higher in the 37 patients who developed postoperative pancreatic fistulas (POPFs) than in the patients who had uneventful recoveries (n=61). Moreover, the serum levels of calprotectin and calgranulin C demonstrated a significant predictive value for the development of POPF; the predictive values of these two proteins were better than those of the serum level of C-reactive protein and the white blood cell count. Taken together, the results of this study suggest that calprotectin and calgranulin C serum levels are potential biomarkers for pancreatic tumors, surgical injury to the pancreatic tissue and the development of POPFs.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/NV15-30186A" target="_blank" >NV15-30186A: Alarmins in the development and diagnostics of septic complications of tissue injury</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MEDIATORS OF INFLAMMATION

ISSN

0962-9351

e-ISSN

—

Volume of the periodical

2019

Issue of the periodical within the volume

SEP 9

Country of publishing house

GB - UNITED KINGDOM

Number of pages

1

Pages from-to

"nestránkováno"

UT code for WoS article

000487743200003

EID of the result in the Scopus database

2-s2.0-85072691208