Radiofrequency Ablation in Patients with Barrett's Esophagus-related Neoplasia - Long-Term Outcomes in the Czech National Database

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F19%3A00000556" target="_blank" >RIV/61383082:_____/19:00000556 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00112951 RIV/00216208:11110/19:10395685 RIV/00216208:11150/19:10395685 RIV/00023001:_____/19:00078122 RIV/61988987:17110/19:A21026Z6

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/31204400" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/31204400</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15403/jgld-174" target="_blank" >10.15403/jgld-174</a>

Result language

angličtina

Original language name

Radiofrequency Ablation in Patients with Barrett's Esophagus-related Neoplasia - Long-Term Outcomes in the Czech National Database

Original language description

Background & Aims: Radiofrequency ablation (RFA) with/without endoscopic resection (ER) is the standard endoscopic treatment modality for Barrett's esophagus (BE) related neoplasia (BORN). The main aim of this study was to assess the long-term outcomes of RFA in patients with BORN. Methods: We retrospectively analyzed the prospectively collected data from the Czech national database. Main outcomes were: complete remission of neoplasia (CR-N), complete remission of intestinal metaplasia (CR-IM), recurrence of both neoplasia and IM, and safety. Results: From a total of 170 patients with BORN treated with RFA, 136 patients were analyzed. They were followed up for a median of 27.5 months. Fifty-six patients (41%) had low-grade intraepithelial neoplasia (LGIN), 46 (34%) had high-grade intraepithelial neoplasia (HGIN) and 34 (25%) had early adenocarcinoma (EAC). RFA was combined with previous ER in 65 patients (48%). CR-IM and CR-N were achieved in 77.9% (95% CI 70.0-84.6%) and 98.5% (95% CI 94.8-99.8%). Among 30 patients without CR-IM, 22 (73%) did not have macroscopic signs of BE. Recurrent neoplasia was detected in 4.5% of patients (6/134) and 15% (16/106) experienced a recurrence of IM at the level of the neo-Z-line. Diagnosis of cancer was an independent risk factor for recurrent IM after RFA (OR 7.0, 95% CI 1.6-30.9, p<0.0005). Conclusion: RFA is highly effective in achieving remission in patients with BORN. A significant proportion of patients did not achieve CR-IM or had a recurrence of IM despite macroscopically absent BE. Recurrence of neoplasia was infrequent but not negligible, thus, patients after successful RFA still require endoscopic surveillance.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

<a href="/en/project/NV16-27648A" target="_blank" >NV16-27648A: Probe-based confocal laser endomicroscopy in accurate histopathologic diagnosis of neoplastic gastrointestinal lesions</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES

ISSN

1841-8724

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

2

Country of publishing house

RO - ROMANIA

Number of pages

7

Pages from-to

149-155

UT code for WoS article

000475570900006

EID of the result in the Scopus database

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