Radiofrequency ablation in patients with Barretts´s esophagus-related neoplasia. Long term outcomes in the Czech national database

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73594775" target="_blank" >RIV/61989592:15110/19:73594775 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/19:N0000029

Result on the web

<a href="https://www.jgld.ro/jgld/index.php/jgld/article/view/174/114" target="_blank" >https://www.jgld.ro/jgld/index.php/jgld/article/view/174/114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15403/jgld-174" target="_blank" >10.15403/jgld-174</a>

Result language

angličtina

Original language name

Radiofrequency ablation in patients with Barretts´s esophagus-related neoplasia. Long term outcomes in the Czech national database

Original language description

Abstract Background &amp; Aims: Radiofrequency ablation (RFA) with/without endoscopic resection (ER) is the standard endoscopic treatment modality for Barrett&apos;s esophagus (BE) related neoplasia (BORN). The main aim of this study was to assess the long-term outcomes of RFA in patients with BORN. Methods: We retrospectively analyzed the prospectively collected data from the Czech national database. Main outcomes were: complete remission of neoplasia (CR-N), complete remission of intestinal metaplasia (CR-IM), recurrence of both neoplasia and IM, and safety. Results: From a total of 170 patients with BORN treated with RFA, 136 patients were analyzed. They were followed up for a median of 27.5 months. Fifty-six patients (41%) had low-grade intraepithelial neoplasia (LGIN), 46 (34%) had high-grade intraepithelial neoplasia (HGIN) and 34 (25%) had early adenocarcinoma (EAC). RFA was combined with previous ER in 65 patients (48%). CR-IM and CR-N were achieved in 77.9% (95% CI 70.0-84.6%) and 98.5% (95% CI 94.8-99.8%). Among 30 patients without CR-IM, 22 (73%) did not have macroscopic signs of BE. Recurrent neoplasia was detected in 4.5% of patients (6/134) and 15% (16/106) experienced a recurrence of IM at the level of the neo-Z-line. Diagnosis of cancer was an independent risk factor for recurrent IM after RFA (OR 7.0, 95% CI 1.6-30.9, p&lt;0.0005). Conclusion: RFA is highly effective in achieving remission in patients with BORN. A significant proportion of patients did not achieve CR-IM or had a recurrence of IM despite macroscopically absent BE. Recurrence of neoplasia was infrequent but not negligible, thus, patients after successful RFA still require endoscopic surveillance.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Gastrointestinal and Liver Diseases

ISSN

1841-8724

e-ISSN

—

Volume of the periodical

28

Issue of the periodical within the volume

2

Country of publishing house

RO - ROMANIA

Number of pages

7

Pages from-to

149-155

UT code for WoS article

000475570900006

EID of the result in the Scopus database

2-s2.0-85068228566