Elevated regulatory T cells after antibiotic treatment of infectious spondylodiscitis as biomarker of recovery?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F23%3A00001289" target="_blank" >RIV/61383082:_____/23:00001289 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/23:10465912
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/37075915/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/37075915/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.imlet.2023.04.006" target="_blank" >10.1016/j.imlet.2023.04.006</a>
Alternative languages
Result language
angličtina
Original language name
Elevated regulatory T cells after antibiotic treatment of infectious spondylodiscitis as biomarker of recovery?
Original language description
Dysregulated systemic immune responses during infectious spondylodiscitis (IS) may impair microbial clearance and bone resorption. Therefore, the aim of the study was to examine whether circulating regulatory T cells (Tregs) are elevated during IS and whether their frequency is associated with alterations in T cells and the presence of markers of bone resorption in the blood. A total of 19 patients hospitalized with IS were enrolled in this prospective study. Blood specimens were obtained during hospitalization and 6 weeks and 3 months after discharge. Flow cytometric analysis of CD4 and CD8 T cell subsets, the percentage of Tregs and serum levels of collagen type I fragments (S-CrossLap) were performed. Out of 19 enrolled patients with IS, microbial etiology was confirmed in 15 (78.9%) patients. All patients were treated with antibiotics for a median of 42 days, and no therapy failure was observed. Next, a significant serum C-reactive protein (S-CRP) decrease during the follow-up was observed, whereas the frequencies of Tregs remained higher than those of controls at all-time points (p < 0.001). In addition, Tregs demonstrated a weak negative correlation with S-CRP and S-CrossLap levels were within the norm at all-time points. Circulating Tregs were elevated in patients with IS and this elevation persisted even after the completion of antibiotic therapy. Moreover, this elevation was not associated with treatment failure, altered T cells, or increased markers of bone resorption.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IMMUNOLOGY LETTERS
ISSN
0165-2478
e-ISSN
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Volume of the periodical
256
Issue of the periodical within the volume
Apr
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
4
Pages from-to
55-58
UT code for WoS article
000990679500001
EID of the result in the Scopus database
2-s2.0-85152669765