Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F25%3A00001515" target="_blank" >RIV/61383082:_____/25:00001515 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/25:00616890 RIV/00216208:11110/25:10491367 RIV/65269705:_____/25:00081482 RIV/00098892:_____/25:10159059 and 2 more
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/39880897/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/39880897/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-025-87882-z" target="_blank" >10.1038/s41598-025-87882-z</a>
Alternative languages
Result language
angličtina
Original language name
Risk factors associated with higher WHO grade in meningiomas: a multicentric study of 552 skull base meningiomas
Original language description
The histological grade is crucial for therapeutic management, and its reliable preoperative detection can significantly influence treatment approach. Lacking established risk factors, this study identifies preoperative predictors of high-grade skull base meningiomas and discusses the implications of non-invasive detection. A multicentric study was conducted on 552 patients with skull base meningiomas who underwent primary surgical resection between 2014 and 2019. Data were gathered from clinical, surgical and pathology records and radiological diagnostics. The predictive factors of higher WHO grade were analysed in univariate analysis and multivariate stepwise selection logistic regression analysis. Histological analysis revealed 511 grade 1 (92.6%) and 41 grade 2 (7.4%) meningiomas. A prognostic model predicting the probability of WHO grade 2 skull base meningioma (AUC 0.79; SE 0.04; 95% Wald Confidence Limits (0.71; 0.86)) based on meningioma diameter, presence of an arachnoid plane and cranial nerve palsy was built. Accurate preoperative detection of WHO grade in skull base meningiomas is essential for effective treatment planning. Our logistic regression model, based on diameter, cranial nerve palsy, and arachnoid plane, is tailored for detecting WHO grade 2 skull base meningiomas, even in outpatient settings.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NW25J-08-00088" target="_blank" >NW25J-08-00088: Integration of biomechanical profiling for risk stratification and optimal treatment of patients with meningiomas</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SCIENTIFIC REPORTS
ISSN
2045-2322
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
1-11
UT code for WoS article
001410922100022
EID of the result in the Scopus database
2-s2.0-85217357903