Role of risk factors, scoring systems, and prognostic models in predicting the functional outcome in meningioma surgery: multicentric study of 552 skull base meningiomas

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F23%3A00572702" target="_blank" >RIV/67985807:_____/23:00572702 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10465902 RIV/00098892:_____/23:10158027 RIV/00843989:_____/23:E0110287 RIV/00669806:_____/23:10465902 and 2 more

Result on the web

<a href="https://dx.doi.org/10.1007/s10143-023-02004-5" target="_blank" >https://dx.doi.org/10.1007/s10143-023-02004-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10143-023-02004-5" target="_blank" >10.1007/s10143-023-02004-5</a>

Result language

angličtina

Original language name

Role of risk factors, scoring systems, and prognostic models in predicting the functional outcome in meningioma surgery: multicentric study of 552 skull base meningiomas

Original language description

Despite the importance of functional outcome, only a few scoring systems exist to predict neurologic outcome in meningioma surgery. Therefore, our study aims to identify preoperative risk factors and develop the receiver operating characteristics (ROC) models estimating the risk of a new postoperative neurologic deficit and a decrease in Karnofsky performance status (KPS). A multicentric study was conducted in a cohort of 552 consecutive patients with skull base meningiomas who underwent surgical resection from 2014 to 2019. Data were gathered from clinical, surgical, and pathology records as well as radiological diagnostics. The preoperative predictive factors of functional outcome (neurologic deficit, decrease in KPS) were analyzed in univariate and multivariate stepwise selection analyses. Permanent neurologic deficits were present in 73 (13.2%) patients and a postoperative decrease in KPS in 84 (15.2%). Surgery-related mortality was 1.3%. A ROC model was developed to estimate the probability of a new neurologic deficit (area 0.74, SE 0.0284, 95% Wald confidence limits (0.69, 0.80)) based on meningioma location and diameter. Consequently, a ROC model was developed to predict the probability of a postoperative decrease in KPS (area 0.80, SE 0.0289, 95% Wald confidence limits (0.74, 0.85)) based on the patient's age, meningioma location, diameter, presence of hyperostosis, and dural tail. To ensure an evidence-based therapeutic approach, treatment should be founded on known risk factors, scoring systems, and predictive models. We propose ROC models predicting the functional outcome of skull base meningioma resection based on the age of the patient, meningioma size, and location and the presence of hyperostosis and dural tail.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NV19-04-00272" target="_blank" >NV19-04-00272: Relationship of meningioma origo to arachnoid membranes, extent of resection and surgical risks</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurosurgical Review

ISSN

0344-5607

e-ISSN

1437-2320

Volume of the periodical

46

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

124

UT code for WoS article

000993847300001

EID of the result in the Scopus database

2-s2.0-85160006715