MRI-and CT-derived carotid plaque characteristics and stroke: Insights from the ANTIQUE study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F25%3A00001521" target="_blank" >RIV/61383082:_____/25:00001521 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/25:A2603ATX RIV/00216208:11110/25:10489588 RIV/00216208:11130/25:10489588 RIV/00216208:11150/25:10489588 and 4 more
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/39743911/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/39743911/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.33963/v.phj.103740" target="_blank" >10.33963/v.phj.103740</a>
Alternative languages
Result language
angličtina
Original language name
MRI-and CT-derived carotid plaque characteristics and stroke: Insights from the ANTIQUE study
Original language description
Background: Carotid plaque composition plays a key role in plaque stability and patient risk stratification. Of unstable plaque features, intraplaque hemorrhage (IPH) is considered the main risk factor for stroke development. Aims: We aimed to assess an association between the presence of IPH and other plaque characteristics detectable by computed tomography (CT) or magnetic resonance imaging (MRI) and stroke. Material and methods: Of all consecutive patients from the ANTIQUE study, 132 (91 males; aged 70.0 [8.6] years) with 59 symptomatic and 157 asymptomatic stable carotid plaques were included in the retrospective analysis of prospectively collected data. Plaques in the vascular territory of ischemic stroke within 90 days were classified as symptomatic and were diagnosed by CT and MRI after symptoms occurred. Plaques without progression and clinical infarction were classified as asymptomatic stable. Univariate and multivariate logistic regression analyses were performed to identify risk factors. Results: The presence, age, location, and volume of IPH were not related to stroke risk (P >0.05). Patients with symptomatic plaque were more likely to consume alcohol (P= 0.005), had more severe stenosis (CT median: 80% vs. 72%; P = 0.005; MRI median: 79% vs. 72%; P = 0.01), lower American Heart Association grade (P= 0.03), and more frequent lipid plaque (89.8% vs. 76.4%; P= 0.04) compared to patients with asymptomatic stable plaques. Stenosis severity (odds ratio [OR], 1.037; 95% CI, 1.015–1.059) and additionally alcohol consumption (OR, 3.571; 95% CI, 1.694–7.527) were found to be the only significant predictors of a recent stroke. Conclusions: In this cohort, no IPH or other plaque characteristics were associated with stroke risk. The degree of stenosis and alcohol consumption were the only factors associated with ipsilateral stroke. Larger prospective studies considering plaque characteristics are needed.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Polish Heart Journal-Kardiologia Polska
ISSN
0022-9032
e-ISSN
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Volume of the periodical
83
Issue of the periodical within the volume
3
Country of publishing house
PL - POLAND
Number of pages
10
Pages from-to
277 - 286
UT code for WoS article
001464158100005
EID of the result in the Scopus database
2-s2.0-105001925168