Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F25%3A00001522" target="_blank" >RIV/61383082:_____/25:00001522 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/25:10500097

Result on the web

<a href="http://Impact" target="_blank" >http://Impact</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5946/ce.2024.347" target="_blank" >10.5946/ce.2024.347</a>

Result language

angličtina

Original language name

Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols

Original language description

Background/Aims: Propofol is the most effective sedative for colonoscopy; however, opioids do have several adverse effects that need to be discussed. The objective of this study was to compare the ease of colonoscopy during propofol-based sedation with and without fentanyl, while closely monitoring ventilatory data and the safety of the procedure.Methods: This prospective single-center trial randomized 50 patients who underwent minor colonoscopies. The propofol group re ceived sedation exclusively via propofol, whereas the propofol+fentanyl group was premedicated with 1 µg/kg fentanyl. Patients were monitored using a bioimpedance ventilatory monitor, and both the patients and endoscopists were questioned regarding their level of satisfaction. Results: The endoscopists reported a higher level of ease with the colonoscopy procedure (mean on a 5-point scale, 1.2 vs. 1.72; p=0.028) and the overall patient satisfaction score was higher (1.15 vs. 1.28, p=0.026) in the propofol+fentanyl group. No significant differences were observed in the ventilatory parameters between the groups. No major adverse events were reported in any of the groups. Conclusions: The inclusion of fentanyl leads to enhanced levels of satisfaction for both the endoscopist and the patient, without any impact on ventilation and safety. The use of bioimpedance monitoring of ventilation during colonoscopy is a suitable approach that may enhance the safety of procedural sedation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Endoscopy

ISSN

2234-2400

e-ISSN

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Volume of the periodical

2025

Issue of the periodical within the volume

Jul 4

Country of publishing house

KR - KOREA, REPUBLIC OF

Number of pages

9

Pages from-to

1-9

UT code for WoS article

001525067700001

EID of the result in the Scopus database

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