Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21460%2F25%3A00384097" target="_blank" >RIV/68407700:21460/25:00384097 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.5946/ce.2024.347" target="_blank" >https://doi.org/10.5946/ce.2024.347</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5946/ce.2024.347" target="_blank" >10.5946/ce.2024.347</a>
Alternative languages
Result language
angličtina
Original language name
Impact of opioid addition on procedural conditions during colonoscopy: a randomized trial comparing propofol-based sedation protocols
Original language description
Background/Aims Propofol is the most effective sedative for colonoscopy; however, opioids do have several adverse effects that need to be discussed. The objective of this study was to compare the ease of colonoscopy during propofol-based sedation with and without fentanyl, while closely monitoring ventilatory data and the safety of the procedure. Methods This prospective single-center trial randomized 50 patients who underwent minor colonoscopies. The propofol group received sedation exclusively via propofol, whereas the propofol+fentanyl group was premedicated with 1 µg/kg fentanyl. Patients were monitored using a bioimpedance ventilatory monitor, and both the patients and endoscopists were questioned regarding their level of satisfaction. Results The endoscopists reported a higher level of ease with the colonoscopy procedure (mean on a 5-point scale, 1.2 vs. 1.72; p=0.028) and the overall patient satisfaction score was higher (1.15 vs. 1.28, p=0.026) in the propofol+fentanyl group. No significant differences were observed in the ventilatory parameters between the groups. No major adverse events were reported in any of the groups. Conclusions The inclusion of fentanyl leads to enhanced levels of satisfaction for both the endoscopist and the patient, without any impact on ventilation and safety. The use of bioimpedance monitoring of ventilation during colonoscopy is a suitable approach that may enhance the safety of procedural sedation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Endoscopy
ISSN
2234-2443
e-ISSN
2234-2443
Volume of the periodical
58
Issue of the periodical within the volume
5
Country of publishing house
KR - KOREA, REPUBLIC OF
Number of pages
9
Pages from-to
722-730
UT code for WoS article
001525067700001
EID of the result in the Scopus database
2-s2.0-105020726156