Investigation of nanoparticle coating by fluorescence correlation spectroscopy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F08%3A00311010" target="_blank" >RIV/61388955:_____/08:00311010 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/08:00311010
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Investigation of nanoparticle coating by fluorescence correlation spectroscopy
Original language description
Protecting gene delivery vectors by hydrophilic copolymer coating is a promising approach in targeted gene therapy. Herein we demonstrate the usefulness of FCS in characterizing the coating process of a virus model - latex beads with coumarin-labeled N-(2-hydroxypropyl)methacrylamide copolymer containing thiazolidine-2-thione groups. FCS gives an estimation of the average number of polymer chains coating the latex bead, which agrees with light scattering results, giving an evidence of quality of the vector surface modification. FCS is advantageous because it decreases the sample consumption by a factor of 1 000. The coumarin label showed advantages over the previously used fluorescein-based one.
Czech name
Výzkum nanočástic ve fluorescenční korelační spektroskopii
Czech description
Výzkum nanočástic ve fluorescenční korelační spektroskopii.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)