New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F13%3A00393961" target="_blank" >RIV/61388955:_____/13:00393961 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bpc.2013.06.010" target="_blank" >http://dx.doi.org/10.1016/j.bpc.2013.06.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bpc.2013.06.010" target="_blank" >10.1016/j.bpc.2013.06.010</a>

Result language

angličtina

Original language name

New gluconamide-type cationic surfactants: Interactions with DNA and lipid membranes

Original language description

New linear cationic surfactants ? 2-(alkyldimethylammonio)ethylgluconamide bromides, denoted as CnGAB, n = 10, 12, 14 and 16 ? were synthesized from natural resources and characterized with respect to their potential as gene-delivery agents in gene therapy applications. Interactions with plasmid DNA and with model membranes were studied both experimentally and theoretically. The compounds with n = 12, 14 and 16 show exponentially increasing ability to fully condense DNA. C16GAB condenses DNA at 1:1 surfactant to nucleotide molar ratio. Furthermore, CnGABs interact with model membrane, slightly lowering the temperature of the main phase transition Tm of the DPPC bilayer. C10GAB is found to interact only at the membrane surface. C16GAB reduces Tm less than C12GAB and C14GAB, and forms domains in the bilayer at the surfactant/DPPC molar ratio of 0.1 and higher. The results suggest that C16GAB can be a promising candidate for building gene-delivery carrier systems.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

<a href="/en/project/GBP208%2F12%2FG016" target="_blank" >GBP208/12/G016: Controlling structure and function of biomolecules at the molecular scale: theory meets experiment</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biophysical Chemistry

ISSN

0301-4622

e-ISSN

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Volume of the periodical

180-181

Issue of the periodical within the volume

OCT-NOV

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

44-54

UT code for WoS article

000324898700006

EID of the result in the Scopus database

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