The alteration of lipid bilayer dynamics by phloretin and 6-ketocholestanol

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F14%3A00424577" target="_blank" >RIV/61388955:_____/14:00424577 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.chemphyslip.2013.11.005" target="_blank" >http://dx.doi.org/10.1016/j.chemphyslip.2013.11.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.chemphyslip.2013.11.005" target="_blank" >10.1016/j.chemphyslip.2013.11.005</a>

Result language

angličtina

Original language name

The alteration of lipid bilayer dynamics by phloretin and 6-ketocholestanol

Original language description

Lipid bilayer properties are quantified with a variety of arbitrary selected parameters such as molecular packing and dynamics, electrostatic potentials or permeability. In the paper we determined the effect of phloretin and 6-ketocholestanol (dipole potential modifying agents) on the membrane hydration and efficiency of the trans-membrane water flow. The dynamics of water molecules within the lipid bilayer interface was evaluated using solvent relaxation method, whereas the osmotically induced trans-membrane water flux was estimated with the stopped-flow method using the liposome shrinkage kinetics. The presence of phloretin or 6-ketocholestanol resulted in a change of both, the interfacial hydration level and osmotically driven water fluxes. Specifically, the presence of 6-ketocholestanol reduced the amount and mobility of water in the membrane interface. It also slows the osmotically induced water flow. The interfacial hydration change caused by phloretin was much smaller and the ef

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry and Physics of Lipids

ISSN

0009-3084

e-ISSN

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Volume of the periodical

178

Issue of the periodical within the volume

FEB 2014

Country of publishing house

IE - IRELAND

Number of pages

7

Pages from-to

38-44

UT code for WoS article

000331687200005

EID of the result in the Scopus database

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