On reduction of the drug diflunisal in non-aqueous media

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F15%3A00438991" target="_blank" >RIV/61388955:_____/15:00438991 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00706-014-1390-7" target="_blank" >http://dx.doi.org/10.1007/s00706-014-1390-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-014-1390-7" target="_blank" >10.1007/s00706-014-1390-7</a>

Result language
angličtina
Original language name
On reduction of the drug diflunisal in non-aqueous media
Original language description
The electrochemical reduction of diflunisal was studied in dimethyl sulfoxide on static mercury drop electrode. Diflunisal yields one irreversible wave at 1.2 V (vs. Ag | AgCl | 1 M LiCl electrode) due to the reduction of the carboxylic functional groupin the molecule. The electrochemical properties of the drug were compared with the ones of the chlorinated analogue. The study is based on cyclic voltammetry, tast polarography, and constant potential electrolysis. The experimental findings are supportedby molecular orbital calculations. The mechanism of reduction of the carboxylic moiety was found to involve two electrons and two protons. The reduction pathway leads to formation of an aldehyde derivative.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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