Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F15%3A00452358" target="_blank" >RIV/61388955:_____/15:00452358 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1183/23120541.00044-2015" target="_blank" >http://dx.doi.org/10.1183/23120541.00044-2015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00044-2015" target="_blank" >10.1183/23120541.00044-2015</a>

Result language

angličtina

Original language name

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis

Original language description

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeruginosa infection.nn233 children with CF who were free from P. aeruginosa infection were followed for 2?years. Their median (interquartile range) age was 8.0 (5.0?12.2)?years. At each study visit, an exhaled breath sample was collected for hydrogen cyanideanalysis. In total, 2055 breath samples were analysed. At the end of the study, the hydrogen cyanide concentrations were compared to the results of routine microbiology surveillance.nnP. aeruginosa was isolated from 71 children during the study with anincidence (95% CI) of 0.19 (0.15?0.23) cases per patient-year. Using a random-effects logistic model, the estimated odds ratio (95% CI) was 3.1 (2.6?3.6), which showed that for a 1-?ppbv increase in exhaled breath hydrogen cyanide, we ex

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ERJ Open Research

ISSN

2312-0541

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

2015

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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