Markers of Oxidative Damage of Nucleic Acids and Proteins among Workers Exposed to TiO2 (nano) Particles.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F16%3A00452180" target="_blank" >RIV/61388955:_____/16:00452180 - isvavai.cz</a>
Alternative codes found
RIV/67985858:_____/16:00452180 RIV/00216208:11110/16:10324974 RIV/00216208:11510/16:10324974 RIV/60461373:22310/16:43902604 RIV/00064165:_____/16:10324974
Result on the web
<a href="http://dx.doi.org/10.1136/oemed-2015-103161" target="_blank" >http://dx.doi.org/10.1136/oemed-2015-103161</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/oemed-2015-103161" target="_blank" >10.1136/oemed-2015-103161</a>

Result language
angličtina
Original language name
Markers of Oxidative Damage of Nucleic Acids and Proteins among Workers Exposed to TiO2 (nano) Particles.
Original language description
The use of nanotechnology is growing enormously and occupational physicians have an increasing interest in evaluating potential hazards and finding biomarkers of effect in workers exposed to nanoparticles. A study was carried out with 36 workers exposedto (nano)TiO2 pigment and 45 controls. Condensate (EBC) titanium and markers of oxidation of nucleic acids (including 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU)) and proteins (such as o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr) and 3-nitrotyrosine (3-NOTyr)) were analysed from samples of their exhaled breath. In the production workshops, the median total mass 2012 and 2013 TiO2 concentrations were 0.65 and 0.40?mg/m(3), respectively. The median numbers of concentrations measured by the scanning mobility particle sizer (SMPS) and aerodynamic particle sizer (APS) were 1.98*10(4) and 2.32*10(4) particles/cm(3), respectively; and about 80% of those particles were smaller than 100?nm
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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