Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00471287" target="_blank" >RIV/61388955:_____/17:00471287 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10334979 RIV/65269705:_____/17:00066271 RIV/00064165:_____/17:10334979
Result on the web
<a href="http://dx.doi.org/10.1080/15563650.2016.1250901" target="_blank" >http://dx.doi.org/10.1080/15563650.2016.1250901</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15563650.2016.1250901" target="_blank" >10.1080/15563650.2016.1250901</a>
Alternative languages
Result language
angličtina
Original language name
Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning
Original language description
Context: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined.nObjective: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning.nMethods: The study was designed as observational cohort study. The mean time for an increase of 1 mmol/L HCO3-, 0.01 unit arterial blood pH, and the total time for correction of HCO3- were determined in IHD- and CRRT-treated patients.nResults: Data were obtained from 18 patients treated with IHD and 13 patients treated with CRRT. At baseline, CRRT group was more acidemic than IHD group (mean arterial pH 6.790.10 versus 7.050.10, p=0.001). No association was found between the rate of acidemia correction and age, weight, serum methanol, lactate, formate, and glucose on admission. The time to HCO3- correction correlated with arterial blood pH (r=-0.511, p=0.003) and creatinine (r=0.415, p=0.020). There was association between the time to HCO3- correction and dialysate/effluent and blood flow rates (r=-0.738, p<0.001 and r=-0.602, p<0.001, correspondingly).nThe mean time for HCO3- to increase by 1mmol/L was 12 +/- 2 min for IHD versus 34 +/- 8 min for CRRT (p<0.001), and the mean time for arterial blood pH to increase 0.01 was 7 +/- 1 mins for IHD versus 11 +/- 4 min for CRRT (p=0.024). The mean increase in HCO3- was 5.67 +/- 0.90 mmol/L/h for IHD versus 2.17 +/- 0.74 mmol/L/h for CRRT (p<0.001).nConclusions: Our study supports the superiority of IHD over CRRT in terms of the rate of acidemia correction.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVE PROCESSES IN PATIENTS EXPOSED TO METHANOL: PROSPECTIVE STUDY AFTER CZECH MASS METHANOL POISONING OUTBREAK IN 2012</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CLINICAL TOXICOLOGY
ISSN
1556-3650
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
123-132
UT code for WoS article
000393890500008
EID of the result in the Scopus database
2-s2.0-84994274919