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Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00471287" target="_blank" >RIV/61388955:_____/17:00471287 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11110/17:10334979 RIV/65269705:_____/17:00066271 RIV/00064165:_____/17:10334979

  • Result on the web

    <a href="http://dx.doi.org/10.1080/15563650.2016.1250901" target="_blank" >http://dx.doi.org/10.1080/15563650.2016.1250901</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/15563650.2016.1250901" target="_blank" >10.1080/15563650.2016.1250901</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning

  • Original language description

    Context: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined.nObjective: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning.nMethods: The study was designed as observational cohort study. The mean time for an increase of 1 mmol/L HCO3-, 0.01 unit arterial blood pH, and the total time for correction of HCO3- were determined in IHD- and CRRT-treated patients.nResults: Data were obtained from 18 patients treated with IHD and 13 patients treated with CRRT. At baseline, CRRT group was more acidemic than IHD group (mean arterial pH 6.790.10 versus 7.050.10, p=0.001). No association was found between the rate of acidemia correction and age, weight, serum methanol, lactate, formate, and glucose on admission. The time to HCO3- correction correlated with arterial blood pH (r=-0.511, p=0.003) and creatinine (r=0.415, p=0.020). There was association between the time to HCO3- correction and dialysate/effluent and blood flow rates (r=-0.738, p<0.001 and r=-0.602, p<0.001, correspondingly).nThe mean time for HCO3- to increase by 1mmol/L was 12 +/- 2 min for IHD versus 34 +/- 8 min for CRRT (p<0.001), and the mean time for arterial blood pH to increase 0.01 was 7 +/- 1 mins for IHD versus 11 +/- 4 min for CRRT (p=0.024). The mean increase in HCO3- was 5.67 +/- 0.90 mmol/L/h for IHD versus 2.17 +/- 0.74 mmol/L/h for CRRT (p<0.001).nConclusions: Our study supports the superiority of IHD over CRRT in terms of the rate of acidemia correction.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    <a href="/en/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVE PROCESSES IN PATIENTS EXPOSED TO METHANOL: PROSPECTIVE STUDY AFTER CZECH MASS METHANOL POISONING OUTBREAK IN 2012</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    CLINICAL TOXICOLOGY

  • ISSN

    1556-3650

  • e-ISSN

  • Volume of the periodical

    55

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    123-132

  • UT code for WoS article

    000393890500008

  • EID of the result in the Scopus database

    2-s2.0-84994274919