Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00476996" target="_blank" >RIV/61388955:_____/17:00476996 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10364214 RIV/00064165:_____/17:10364214

Result on the web

<a href="http://dx.doi.org/10.1186/s13613-017-0300-7" target="_blank" >http://dx.doi.org/10.1186/s13613-017-0300-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13613-017-0300-7" target="_blank" >10.1186/s13613-017-0300-7</a>

Result language

angličtina

Original language name

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Original language description

Background: Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors.nMethods: The study was designed as prospective observational cohort study. Patients hospitalized with a diagnosis of acute methanol poisoning were identified for the study. Exploratory factor analysis and multivariate logistic regression were applied to determine the effect of ECTR modality on the outcome.nResults: Data were obtained from 41 patients treated with IHD and 40 patients with CRRT. The follow-up time in survivors was two years. Both groups of patients were comparable by age, time to presentation, laboratory data, clinical features, and other treatment applied. The CRRT group was more acidemic (arterial blood pH 6.96 +/- 0.08 vs. 7.17 +/- 0.07, p < 0.001) and more severely poisoned (25/40 vs. 9/41 patients with Glasgow Coma Scale (GCS) <= 8, p < 0.001). The median intensive care unit length of stay (4 (range 1-16) days vs. 4 (1-22) days, p = 0.703) and the number of patients with complications during the treatment (11/41 vs. 13/40 patients, p = 0.576) did not differ between the groups. The mortality was higher in the CRRT group (15/40 vs. 5/41, p = 0.008). The number of survivors without sequelae of poisoning was higher in the IHD group (23/41 vs. 10/40, p = 0.004). There was a significant association of ECTR modality with both mortality and the number of survivors with visual and CNS sequelae of poisoning, but this association was not present after adjustment for arterial blood pH and GCS on admission (all p > 0.05).n

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project

<a href="/en/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVE PROCESSES IN PATIENTS EXPOSED TO METHANOL: PROSPECTIVE STUDY AFTER CZECH MASS METHANOL POISONING OUTBREAK IN 2012</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Intensive Care

ISSN

2110-5820

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

11

Pages from-to

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UT code for WoS article

000406223100002

EID of the result in the Scopus database

2-s2.0-85025449949