Electrochemical Study of Highly Substituted Titanocene Dihalides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F19%3A00508037" target="_blank" >RIV/61388955:_____/19:00508037 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/19:00078257 RIV/00216208:11310/19:10404405
Result on the web
<a href="http://hdl.handle.net/11104/0298992" target="_blank" >http://hdl.handle.net/11104/0298992</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201900464" target="_blank" >10.1002/elan.201900464</a>

Result language
angličtina
Original language name
Electrochemical Study of Highly Substituted Titanocene Dihalides
Original language description
Titanocene dihalides are promising alternative to Cisplatin in cancer chemotherapy which should reduce negative side effects and overcome increasing resistance of cancer cells. Since the mechanism of anti-cancer action is associated with generation of reactive oxygen species (ROS), hence with redox processes, electrochemical investigation of titanocene species would be an important issue, not applied up to now. In this article we report on the electrochemical reduction as well as oxidation of titanocene difluorides and dichlorides where unsubstituted as well as highly substituted titanocene dihalides are compared. The experiments were realized in acetonitrile using various electrode materials. The studied series was completed by a new dimethylsilylene bridged ansa-titanocene difluoride which was characterized by NMR and x-ray crystallography. The influence of structure and substitution on the redox properties was evaluated and, in addition to this, cytotoxicity of studied titanocene dihalides against human ovarian cancer cell lines A2780 and SK-OV-3, as well as against human embryonic kidney cell line HEK293 were screened. Two of highly substituted titanocenes exhibit cytotoxicity comparable with that of Cisplatin.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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