Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156212" target="_blank" >RIV/61989592:15310/15:33156212 - isvavai.cz</a>
Result on the web
<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123595" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123595</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0123595" target="_blank" >10.1371/journal.pone.0123595</a>

Result language
angličtina
Original language name
Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles
Original language description
The moderate-to-high in vitro cytotoxicity against ovarian A2780 (IC50 = 4.7-14.4 mu M), prostate LNCaP (IC50 = 18.7-30.8 mu M) and prostate PC-3 (IC50 = 17.6-42.3 mu M) human cancer cell lines of the platinum(II) cyclobutane-1,1'-dicarboxylato complexes[Pt(cbdc)(naza)2] (1-6; cbdc = cyclobutane-1,1'-dicarboxylate(2-); naza = halogeno-substituted 7-azaindoles), derived from the anticancer metallodrug carboplatin, are reported. The complexes containing the chloro-and bromo-substituted 7-azaindoles (1, 2, and 4-6) showed a significantly higher (p < 0.05) cytotoxicity against A2780 cell line as compared to cisplatin used as a reference drug. Addition of the non-toxic concentration (5.0 mu M) of L-buthionine sulfoximine (L-BSO, an effective inhibitor of.-glutamylcysteine synthase) markedly increases the in vitro cytotoxicity of the selected complex 3 against A2780 cancer cell line by a factor of about 4.4. The cytotoxicity against A2780 and LNCaP cells, as well as the DNA platination, wer
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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